Vogelgrippe (avian influenza H5N1) in Afrika - human

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Re: Vogelgrippe (avian influenza H5N1) in Afrika - human

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AVIAN INFLUENZA (134): AFRICAN SUBLINEAGES
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Date: Sat 28 Jul 2007
Source: Journal of General Virology, 88, 2297-2306, 2007 [edited]
<http://jgv.sgmjournals.org/cgi/content/ ... /88/8/2297>


Sublineages of avian influenza detected in Africa
-----------------------------------------------
In Africa, highly pathogenic avian influenza (HPAI) H5N1 virus was
1st detected in northern Nigeria and later also in other regions of
the country. Since then, 7 other African countries have reported H5N1
infections. Ducatez et al. (reference below) describe a comparison of
full-length genomic sequences of H5N1 isolates from 7 chicken farms
in Nigeria and chicken and hooded vultures in Burkina Faso with
earlier H5N1 outbreaks worldwide. In addition, the antigenicity of
Nigerian H5N1 isolates was compared with earlier strains.

All African strains clustered within 3 sublineages denominated A
(south-west Nigeria, Niger), B (south-west Nigeria, Egypt, Djibouti)
and C (northern Nigeria, Burkina Faso, Sudan, Cote d'Ivoire), with
distinct nucleotide and amino acid signatures and distinct
geographical distributions within Africa.

Probable non-African ancestors within the west Asian/Russian/European
lineage distinct from the south-east Asian lineages were identified
for each sublineage. All reported human cases in Africa (Egypt and
Djbouti) were caused by sublineage B.

Substitution rates were calculated on the basis of sequences from 11
strains from a single farm in south-west Nigeria. As H5N1 emerged
essentially at the same time in the north and south-west of Nigeria,
the substitution rates confirmed that the virus probably did not
spread from the north to the south, given the observed sequence
diversity, but that it entered the country via 3 independent
introductions. [Analysis of nucleotide substitution rates indicated
that HPAI H5N1 virus has mutated faster within a single Nigerian farm
than occurred during the course of transit of the virus from Qinghai
Lake to Africa. - Mod.CP]

The strains from Burkina Faso seemed to originate from northern
Nigeria. At least 2 of the sublineages also circulated in Europe in
2006 as seen in Germany, further suggesting that the sublineages had
already emerged outside of Africa and seemed to have followed the
east African/west Asian and Black Sea/Mediterranean flyways of migratory birds.

Reference:
Molecular and antigenic evolution and geographical spread of H5N1
highly pathogenic avian influenza viruses in western Africa.

M. F. Ducatez, C. M. Olinger, A. A. Owoade, Z. Tarnagda, M. C.
Tahita, A. Sow, S. De Landtsheer, W. Ammerlaan, J. B. Ouedraogo, A.
D. M. E. Osterhaus, R. A. M. Fouchier and C. P. Muller.

At The Institute of Immunology, National Public Health Laboratory,
20A rue Auguste Lumiere, L-1950 Luxembourg, Luxembourg; Department of
Veterinary Medicine, University of Ibadan, Ibadan, Nigeria; Institut
de Recherche en Sciences de la Sante, 399 Avenue de la liberte, BP
545 Bobo-Dioulasso, Burkina Faso; Laboratoire National de l'Elevage,
03 BP 7026 Ouagadougou, Burkina Faso; Department of Virology, Erasmus
Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

Journal of General Virology, 88, 2297-2306, 2007:
<http://jgv.sgmjournals.org/cgi/content/ ... /88/8/2297>

--
Communicated by:
ProMED-mail
<promed@promedmail.org>

[On top of the author's main conclusion about the virus following the
African/west Asian and Black Sea/Mediterranean flyway of migratory
birds, indicating that the geographical origin of west African HPAI
H5N1 was not south-east Asia but the central Asian/European region,
it is worthwhile to cite the following observations from their
concluding discussion:

1.All five Nigerian virus isolates tested in the haemagglutination
inhibition assay were antigenically most similar to influenza virus
A/turkey/ Turkey/1/2005, a WHO-recommended vaccine strain.

2. Reservations of the developed countries towards vaccination
against H5N1 delay crucial decisions and prevent rapid action in
Africa. Socio-economic and political hurdles further compromise
control measures, whilst the virus continues to spread and threatens
to become endemic.

Subscribers are encouraged to visit the full text of this
state-of-the-art, thorough paper, which was supported by the
Luxembourg government, FAO and WHO. - Mod.AS]
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Zwei Frauen in Ägypten an Vogelgrippe erkrankt

In Ägypten sind zwei 50 und 22 Jahre alten Frauen positiv auf Vogelgrippe getestet worden. Beide seien mit dem auch für Menschen gefährlichen Virus H5N1 infiziert, teilte die Weltgesundheitsorganisation WHO am Freitag in Genf mit. Die 50-Jährige sei am Montag in ein Krankenhaus eingeliefert worden und befinde sich in kritischem Zustand. Die 22-Jährige, eine Geflügelhändlerin, ist den Angaben zufolge seit Mittwoch im Krankenhaus und erholt sich auf der Intensivstation. Die Zahl der Ägypter, die sich seit dem ersten Auftreten der Krankheit im Februar 2006 mit dem Virus infiziert haben, stieg damit auf insgesamt 41. Davon starben 16. Erst am Mittwoch hatte das ägyptische Gesundheitsministerium den Tod einer an Vogelgrippe erkrankten 25-jährigen Frau bekanntgegeben

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Egyptian woman dies of bird flu, 2nd in week

CAIRO (Reuters) - A 25-year-old Egyptian woman died of bird flu on Sunday, the second fatality among humans in Egypt in less than one week, the Health Ministry said. mehr...

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Re: Vogelgrippe (avian influenza H5N1) in Afrika - human

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Avian influenza - situation in Egypt - update 2
WHO - 02.01.2008


The Ministry of Health and Population, Egypt has announced two new cases of human infection of H5N1 avian influenza. The first case is a 25 years old female from Dekerns District, Dakahlyah Governorate. She developed symptoms on 26 December, was hospitalized on 27 December and died on 30 December. The second case is a 36 years old female from Menof District, Menofia Governorate. She developed symptoms on 26 December, was hospitalized on 29 December and died on 31 December. To date, there has been no evidence of an epidemiological link between this case and the previous case from Menofia Governorate announced on the 28 December. Both women had contact with sick and dead poultry prior to illness onset. Of the 43 cases confirmed to date in Egypt, 18 have been fatal.
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Avian influenza - situation in Egypt - update 3
03.01.2008


The Ministry of Health and Population of Egypt has announced the death of a previously confirmed case of H5N1 infection. The 50 years old female from Domiatt governorate died on 31 December. Of the 43 cases confirmed to date in Egypt, 19 have been fatal.
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Avian influenza - situation in Egypt - update 4
WHO - 28 February 2008

The Ministry of Health and Population of Egypt has announced a new human case of avian influenza A(H5N1) virus infection. The case is a 4 years old female from El-Edwa district, Menia governorate. She developed symptoms on 21 February and was hospitalized on 24 February. She is receiving treatment and is in a stable condition. Investigations into the source of her infection indicate exposure to sick poultry in the week prior to onset of symptoms. Of the 44 cases confirmed to date in Egypt, 19 have been fatal.
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AVIAN INFLUENZA, HUMAN (32): EGYPT
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Egypt - 45th case
Date: Sat 2 Mar 2008
Source: Reuters News [edited]
<http://www.reuters.com/article/middleea ... SL01651795>


A 25-year-old Egyptian woman tested positive for bird flu on Saturday
[2 Mar 2008], the 45th confirmed human case in the Arab world's most
populous country, state news agency MENA said. Ministry of Health
spokesman, Abdel Rahman Shaheen, said the woman had been treated with
the antiviral drug Tamiflu and had been transferred from Fayoum
province to a hospital in Cairo. The woman was suffering from a high
fever; both her lungs were inflamed, and she was being kept on a
respirator and under observation, Shaheen said.

A 4-year-old girl tested positive for bird flu on Monday [25 Feb
2008]. [See: WHO confirmation above].

Four Egyptian women died from bird flu in December [2007]. Their
deaths ended a 5-month pause in human cases in Egypt and brought to
19 the number of Egyptians who have died of the H5N1 bird flu virus
since it emerged in Egypt in early 2006. It is the 3rd winter the
virus has struck after lying low during Egypt's hot summers.

Around 5 million households in Egypt depend on poultry as a main
source of food and income, and the government has said this makes it
unlikely the disease can be eradicated despite a large-scale poultry
vaccination programme. Deaths from bird flu total more than 230
worldwide since 2003 and have been reported in several African and
Asian countries. Egypt has been the worst-hit country outside of Asia.

[Byline: Aziz El-Kaissouni]

--
Communicated by:
ProMED-mail <promed@promedmail.org>

[One of our ProMED correspondents has commented that there is an
overwhelming female bias in mortality in Egypt: only one of 19
confirmed fatalities has been male. This anomaly seems to have
received little attention from the community so far.

A map of the provinces of Egypt can be accessed at
<http://www.map-of-egypt.org/map-of-egypt.gif>.
Al Fayyum province, the site of the 45th case, lies just south of
Cairo and to the north of Al Minya province, the site of the 44th
case. - Mod.CP]
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Avian influenza - situation in Egypt - update 5
WHO - 04.03.2008

The Ministry of Health and Population of Egypt has announced a new human case of avian influenza A(H5N1) virus infection. The case is a 25 years old female from Sennoris District, Fayum Governorate. She developed symptoms on 24 February and was hospitalized on 27 February. Her death has now been confirmed by the Ministry of Health and Population. Investigations into the source of her infection indicate that she had contact with sick poultry prior to becoming unwell. Of the 45 cases confirmed to date in Egypt, 20 have been fatal.
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Avian influenza - situation in Egypt - update 6
WHO - 05.03.2008

The Ministry of Health and Population of Egypt has announced a new human case of avian influenza A(H5N1) virus infection. The case is an 11-year-old male from Menof District, Menofia Governorate. He was hospitalized with symptoms on 26 February and was confirmed as being infected with A(H5N1) by the Central Public Health Laboratory and NAMRU-3 on 4 March. He remains in a critical condition. Investigations into the source of his infection indicate a history of contact with sick and dead poultry. Of the 46 cases confirmed to date in Egypt, 20 have been fatal.
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Egyptian boy confirmed with bird flu, 47th case

An 8-year-old boy in Fayoum province has contracted the bird flu virus after coming into contact with infected birds -- the 47th case among humans in Egypt since 2006, the Health Ministry said on Saturday.

The boy, Abdel Hamid el-Sayed Youssef, was taken to a local hospital with a high temperature, difficulty breathing and a pulmonary inflammation, spokesman Abdel Rahman Shahine said in a statement. mehr...

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IRIN hat geschrieben:EGYPT: New human bird flu case raises fears

CAIRO, 10 March 2008 (IRIN) - An eight-year-old boy from Fayyum province was diagnosed with avian influenza on 8 March, bringing to four the number of human cases in the past two weeks and raising fresh fears of a pandemic.

Since the first human infection was confirmed in February 2006, there have been 47 others, said John Jabbor, a medical officer for emerging diseases with the World Health Organization (WHO).

A 25-year-old woman from Fayyum, the 45th case, died on 4 March, bringing the total number of avian flu deaths to 20. For a country the size of Egypt (population 80 million), this number of deaths is relatively small in general zoonotic diseases (affecting humans and animals) and in human health terms.

After the first outbreak of (HPA1) H5N1, the government adopted several measures to limit its spread and control the disease, as well as the risk of human infections: An estimated 30 million birds were culled and, more recently, there has been widespread free vaccination of private sector commercial flocks and backyard poultry.

Supply chains to blame?

The rapid spread of the disease in Egypt has been related to the development of poultry product supply chains that move millions of birds per day with low levels of biosecurity, according to the UN Food and Agriculture Organization (FAO) report Socio-economic Impacts of Transboundary Animal Diseases in the Near East with Particular Emphasis on Avian Influenza - which was discussed at a FAO regional conference in Cairo 1-5 March.

"More recent outbreaks would appear to be related to the mixture of ducks and chickens in rooftop and backyard systems and their close proximity to industrial poultry units," said the FAO report, which said ducks played a critical role in the maintenance of HPA1 H5N1.

The report also said that although the medical profession is particularly worried that human infections from the H5N1 virus have a 60 percent mortality rate, "the greater concern is that from the current HPA H5N1 in Egypt a virus might emerge that can easily infect humans, spread rapidly from human to human and create a human flu pandemic."

Mainly rural areas affected so far

So far bird flu has hit mostly rural areas in Egypt. A human case from Choubra in 2007 was the only case that was found in Cairo or in any urban area.

Egyptian law forbids raising birds in urban areas, said Abdel-Nasser Abdel-Ghafar, a Ministry of Health and Population representative in the Supreme National Committee for Combating Avian Influenza. However, not everyone abides by the law, he said. Birds are sometimes raised in large cities, and this could be dangerous should infections begin to appear in city poultry, and especially should the virus begin to transfer to humans.

Experts say no human case has occurred in urban areas because in those areas poultry and people do not inhabit the same space - the birds are mostly isolated on rooftops. Generally only one person tends the poultry and children do not play near them, Abdel-Ghafar said.

"In the villages, you will find people and chickens living together," he said. "Changing the culture of people is not easy. [some] people don't believe [the dangers of avian influenza], and they of course will not believe it until something happens to them."

Highest fatality rates outside Asia

Egypt has the highest infection and fatality rates outside of Asia. In addition to Egypt's backyard farm tradition, the density of rural settlements encourages the spread of infected poultry, and could lead to a rapid pandemic, Abdel-Ghafar said.

Yet for many rural dwellers, the threat of bird flu is not enough to convince them to give up this source of income, WHO's Jabbor said. Most human cases of bird flu are among women and children, since women generally tend to the chickens while children play with and around them, he said.

The government, with the help of the WHO, FAO and other UN agencies, is drafting contingency plans in the event of a pandemic. Response teams have been put in place all over the country and each ministry has taken steps to provide services to the people in the event of a pandemic. Shortages of food, electricity, water and access to communications have all been taken into account.

Raising awareness

As many as 14,000 community health workers have been drafted to educate the population about how to deal with sick and dead poultry and how to protect their families from infection, Abdel-Ghafar said. The health workers are all women living in the areas they work in and are known in the community - a tactic used by the government to raise awareness without intimidating villagers by using outsiders.

Poultry vaccinations are provided free of charge to backyard poultry, but not all villagers with a few chickens on their roofs are aware of this, Jabbor said. Farm-raised poultry are raised in controlled environments and are vaccinated. Out of the 47 human cases to date, only two had been working on commercial farms, he said, and neither patient died.

Some villagers hide the fact that they raise poultry in their homes, Abdel-Ghafar said - even when taken to hospital with symptoms of avian influenza. The villagers prefer to protect their birds and livelihoods, he said.
Quelle: http://www.irinnews.org

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AVIAN INFLUENZA (43): EGYPT
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******
Egypt: FAO
Date: Tue 11 Mar 2008
Source: 29th FAO (UN Food & Agriculture Organisation) Regional
Conference for the Middle East, Cairo, 1-5 Mar 2008 [abridged, edited]
<ftp://ftp.fao.org/docrep/fao/meeting/012/k1651e2.pdf>


Highly pathogenic avian influenza - Egypt
-----------------------------------------
After the 1st outbreak of HPAI H5N1 in Egypt in Feb 2006, the
government adopted several mechanisms to limit the spread and control
the disease as well as the risk of human infections. In the control
process, an estimated 30 million birds were culled and, more
recently, there has been widespread free vaccination of private
sector commercial flocks and backyard poultry. As of [11 March 2008,
there had been 46 human cases, 20 of them fatal. - Mod.AS] The rapid
spread of the disease in Egypt has been related to the development of
poultry product supply chains that move millions of birds per day
with low levels of biosecurity. More recent outbreaks would appear to
be related to the mixture of ducks and chickens in the rooftop and
backyard systems and their close proximity to industrial poultry
units. Ducks play a critical role in the maintenance of HPAI H5N1,
and current strengthening of surveillance systems and epidemiological
analysis should allow the development of improved containment
strategies.

For this report, HPAI is viewed in terms of market shock and threat
to livelihoods. While the significant costs in terms of HPAI control
and some loss of international trade are recognized, space and time
do not allow for these to be covered in detail.

The importance of poultry within Egyptian households is unique.
Addressing the impacts avian influenza has had on these households,
in particular the poor and vulnerable families, with actions to
support the affected households is a challenge not just for poultry
health specialists and development specialists but also for national
and local government institutions that need to assess these actions
in light of efforts to reach the Millennium Development Goals.

Significant market shocks to commercial and backyard poultry
operations in Egypt have followed the same sequential pattern in
other countries dealing with HPAI
- during and immediately after an outbreak, demand falters, prices
drop, supplies decline as producers reduce output (birds are culled,
mortality rates increase, or producers respond to reduced consumption
and lower prices), and industry returns decline; and
- markets subsequently recover but the ability of producers to
re-enter the market in a timely fashion may be compromised by various
factors with implications for the long-term structure of the sector.

The food management chains of the industrial chicken sub-sector
(broilers and layers with associated breeding stock which account for
80 percent of the chicken population) have weak contractual
arrangements, poor infrastructure investment, and limited investment
in food processing, marketing, and retailing. It is possible that
this is hampering Egypt's ability to control HPAI and also to compete
in international markets, but this requires further study and
analysis to reach definitive conclusions.

--
Communicated by:
ProMED-mail Rapporteur Mary Marshall

[The above is a summary of this interesting report, which analyses
the socio-economic background and consequences of the Egyptian
epizootic. For the full report (12 pages), particularly conclusions,
see <ftp://ftp.fao.org/docrep/fao/meeting/012/k1651e2.pdf>. - Mod.AS]
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Avian influenza - situation in Egypt - update 7
WHO - 11.03.2008

The Ministry of Health and Population of Egypt has announced a new human case of avian influenza A(H5N1) virus infection. The case is an 8-year-old male from Etsa District, Fayum Governorate. He was hospitalized with symptoms on 3 March. He is receiving treatment and is in a stable condition. Investigations into the source of his infection indicate a history of contact with sick and dead poultry. Of the 47 cases confirmed to date in Egypt, 20 have been fatal.
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Vogelgrippe schlägt erneut in Ägypten zu

In Ägypten ist ein junger Mann an Vogelgrippe gestorben. Er ist das 21. Vogelgrippe-Opfer in dem Land seit dem ersten Auftreten der Krankheit dort im März 2006. Der Mann starb in einem Krankenhaus in Alexandria, wohin er mit hohem Fieber eingeliefert worden war, wie der stellvertretende Gesundheitsminister Nasr al Sajjed der amtlichen Nachrichtenagentur MENA sagte. Nach Indonesien und Vietnam hat Ägypten die weltweit meisten menschlichen Fälle von Vogelgrippe.

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AVIAN INFLUENZA, HUMAN (42): EGYPT
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[1] Egypt - 21st death
Date: Sat 5 Apr 2008
Source: Agence France-Presse (AFP) [edited]
<http://afp.google.com/article/ALeqM5iVj ... IZ89GFqrnA>


An Egyptian teenager died from the H5N1 strain of bird flu on Saturday [5
Apr 2008], the health ministry said, the 21st person to succumb to the
virus since it was discovered here in 2006. The 19 year old teenager from
the Nile Delta province of Beheira died in hospital, health ministry
official Nasr al-Sayyed told the state MENA news agency. "The boy had been
taken to a hospital in the Mediterranean city of Alexandria on Thu 3 Apr
2008 after complaining of high fever and shortness of breath," Sayyed said.
"He had been exposed to infected poultry," he said.

The teenager was the 48th reported case of human bird flu in the country.
In January 2008, 4 people died of the disease in just one week, after
safety precautions had been relaxed with the belief that the virus had
disappeared when no case had been reported in 6 months. Last month [March
2008], a woman died from the virus in Cairo after she was unsuccessfully
treated with Tamiflu [oseltamivir].

Egypt's location on major bird migration routes and the widespread practice
of keeping domestic fowl near living quarters have led to it being the
hardest-hit country outside Asia. The government says it is conducting a
vigorous campaign to combat the spread of the virus through vaccinations
and raising awareness, but experts and officials have warned against people
dropping their guard. Earlier this year [2008], Health Minister Hatem
al-Gabali warned against slackness in the preventative measures taken to
fight bird flu. Health ministry spokesman Abdel Rahman Shahin has
repeatedly urged the public to remain vigilant and deplored the relaxation
of precautions.

Officials have called for the banning of raising fowl in towns and
transporting them between provinces without authorization. They have also
warned sick people that failure to report that they have been in contact
with contaminated domestic fowl makes it more difficult to detect the virus
and to treat it. Women and children have borne the brunt of the virus
because of their role in taking care of domestic fowl.

The World Health Organization (WHO) said earlier this year [2008] that
countries around the world had improved their defenses against bird flu,
but the situation remained critical in Egypt and Indonesia where the risk
of the H5N1 virus mutating into a major human threat remains high. A total
of 238 [239 including the 19 year old. - Mod.CP] have been killed by the
virus worldwide.

--
communicated by:
ProMED-mail rapporteur Mary Marshall

******
[2] Egypt - 21st death
Date: Sat 5 Apr 2008
Source: Reuters News [edited]
<http://africa.reuters.com/wire/news/usnL0586846.html>


An Egyptian man has died of the deadly H5N1 strain of the bird flu virus,
bringing the number of fatalities in Egypt to 21, a WHO official said on
Saturday [5 Apr 2008]. Cairo-based WHO official John Jabbour told Reuters
the 19 year old victim had died on Friday [4 Apr 2008] after falling ill
following contact with infected birds in the Nile Delta province of
Beheira. The man is the 48th Egyptian infected with the H5N1 avian
influenza virus since it arrived in Egypt in February 2006. The Egyptian
News Agency MENA said that the man had been admitted to hospital on
Thursday [3 Apr 2008] after suffering from a high fever, difficulty
breathing, and a pulmonary infection. He was treated with the antiviral
drug Tamiflu [oseltamivir] but did not survive.

A 25 year old woman died of bird flu in Egypt last month [March 2008]. It
is the 3rd winter the virus has struck after lying low during Egypt's hot
summers. About 5 million households in Egypt depend on poultry as a main
source of food and income, and the government has said this makes it
unlikely the disease can be eradicated despite a large scale poultry
vaccination programme.

[byline: Cynthia Johnston]

--
communicated by:
ProMED-mail rapporteur Mary Marshall

[A map of the governorates (provinces) of Egypt can be accessed at
<http://www.map-of-egypt.org/map-of-egypt.gif>. Beheira governorate lies in
the Nile delta region. - Mod.CP]
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